Endogenous retroviruses
نویسندگان
چکیده
Endogenous retroviruses are integral features of vertebrate genomes. Here, Hayward and Katzourakis offer a glimpse into the fascinating world of these mysterious partners in our evolution.
منابع مشابه
Mobilization of endogenous retroviruses in mice after infection with an exogenous retrovirus.
Mammalian genomes harbor a large number of retroviral elements acquired as germ line insertions during evolution. Although many of the endogenous retroviruses are defective, several contain one or more intact viral genes that are expressed under certain physiological or pathological conditions. This is true of the endogenous polytropic retroviruses that generate recombinant polytropic murine le...
متن کاملEndogenous Retroviruses and the Human Genome: Implications for Human Disease
Introduction Lifecycle and Genome Organization Endogenization Process and Host-Virus Evolution Classification of HERVs HERV Manipulation of Host Function Host Defenses against HERVs Cancer Multiple Sclerosis Schizophrenia Azoospermia Conclusions Sources Abstract Human endogenous retroviruses (HERVs) constitute approximately 8% of the human genome (16, 22, 39, 55). These ancient retroviruses rep...
متن کاملMethods for Exploring Genomic Data Sets: Application to Human Endogenous Retroviruses
Oja, M. (2007): Methods for exploring genomic data sets: application to human endogenous retroviruses. Doctoral thesis, Helsinki University of Technology, Dissertations in Computer and Information Science, Report D23, Espoo, Finland.
متن کاملEndogenous retroviruses and multiple sclerosis.
Endogenous retroviruses are normal constituents in vertebrate genomes. They have been associated with various diseases of presumed autoimmune etiology. However, conclusive evidence of their significance as susceptibility factors in these diseases is still lacking. In our laboratory we have focused attention upon endogenous retroviruses as candidate genes in multiple sclerosis. In this communica...
متن کاملInteractions between Exogenous and Endogenous Retroviruses.
Retroviruses are distinguished from other viruses by several features. Notably, some retroviruses are present as normal elements in the genomes of virtually all vertebrates (endogenous proviruses). Others are exogenous, i.e. horizontally transmitted agents, many of which cause fatal diseases. The endogenous retroviruses are genetically transmitted and to a large extent their significance is unc...
متن کاملFoamy-like endogenous retroviruses are extensive and abundant in teleosts
Recent discoveries indicate that the foamy virus (FV) (Spumavirus) ancestor may have been among the first retroviruses to appear during the evolution of vertebrates, demonstrated by foamy endogenous retroviruses present within deeply divergent hosts including mammals, coelacanth, and ray-finned fish. If they indeed existed in ancient marine environments hundreds of millions of years ago, signif...
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ورودعنوان ژورنال:
- Current Biology
دوره 25 شماره
صفحات -
تاریخ انتشار 2015